Neural Architecture of Hunger-Dependent Multisensory Decision Making in C. elegans
- Submitting institution
-
The University of Leeds
- Unit of assessment
- 11 - Computer Science and Informatics
- Output identifier
- UOA11-1406
- Type
- D - Journal article
- DOI
-
10.1016/j.neuron.2016.10.030
- Title of journal
- Neuron
- Article number
- -
- First page
- 1049
- Volume
- 92
- Issue
- 5
- ISSN
- 0896-6273
- Open access status
- Compliant
- Month of publication
- November
- Year of publication
- 2016
- URL
-
-
- Supplementary information
-
https://www.cell.com/neuron/fulltext/S0896-6273(16)30780-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627316307802%3Fshowall%3Dtrue#supplementaryMaterial
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
7
- Research group(s)
-
C - BMH (Applied Computing in Biology, Medicine and Health)
- Citation count
- 38
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This Leeds-Yale collaboration produced among the first studies of sensory integration in C.elegans. We identify a neural circuit for balancing risk-reward, and the associated circuit mechanism for dynamic modulation of risk aversion. Model results were used to formulate experimental hypotheses and validate results. The striking similarity with mammalian top-down modulation of sensation is significant to the wider neuroscience community (see citations, e.g. doi.org/10.1016/j.neuron.2018.10.017). Extensively reviewed in doi.org/10.1016/j.conb.2017.01.005. Multiple invited-keynotes/plenaries (e.g. http://www.eng.biu.ac.il/~shefio/, https://www.dur.ac.uk/psychology/about/news/?itemno=36513). Our bespoke simulator (integrating neural-computation, motility, diffusion) is used by the community for simulating neurodynamics within a whole-animal context, including a follow-up international collaboration (ErasmusMC-Netherlands, https://doi.org/10.1101/2021.03.19.436114).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
