Characterizing Nanoparticles in Biological Matrices: Tipping Points in Agglomeration State and Cellular Delivery In Vitro
- Submitting institution
-
The University of Leeds
- Unit of assessment
- 12 - Engineering
- Output identifier
- CHEM-78
- Type
- D - Journal article
- DOI
-
10.1021/acsnano.7b03708
- Title of journal
- ACS Nano
- Article number
- -
- First page
- 11986
- Volume
- 11
- Issue
- 12
- ISSN
- 1936-0851
- Open access status
- Compliant
- Month of publication
- October
- Year of publication
- 2017
- URL
-
-
- Supplementary information
-
https://ndownloader.figstatic.com/collections/3918985/versions/2
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- Yes
- Number of additional authors
-
8
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- This paper uses quantitative cryo-electron microscopy to provide insight into the dynamic changes occurring during exposure of nanomaterials to cells and proposes a strategy for identifying these changes via a high throughput technique, dynamic light scattering. This is a key and ongoing concern for the development of nanoparticle toxicology and medicine. The work enabled Wills to obtain a Herchel Smith Fellowship at Cambridge University (https://www.herchelsmith.cam.ac.uk/) and our nanoparticle-based collaboration continues through EPSRC grants associated with external user access (EP/R02863X/1) and 3D volume microscopy of hybrid systems (EP/P00122X/1).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
