Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin
- Submitting institution
-
University of Keele
- Unit of assessment
- 12 - Engineering
- Output identifier
- 405
- Type
- D - Journal article
- DOI
-
10.1055/s-0040-1721319
- Title of journal
- Thrombosis and Haemostasis
- Article number
- -
- First page
- 1700
- Volume
- 120
- Issue
- 12
- ISSN
- 0340-6245
- Open access status
- Compliant
- Month of publication
- December
- Year of publication
- 2020
- URL
-
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0040-1721319
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
24
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- An internationally collaborative output, detailing a role for heparin in combatting viral infection, via a rapid response to the COVID-19 pandemic. Input was drawn from 7 distinct organisations drawn from UK, Italy, Brazil, and Australia with funding support from BBSRC (BB/L023717/1; BIVHVB-2020/07/SKIDMORE; BB/S009787/1) and the Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil (2020/04899-1). Immediate impact was noted with over 15 media outlets featuring this output including MeD India (31st Jan 2021), Polish Press Agency (30th Jan 2021), and Sciencenewsnet.in (25th Feb 2021). A follow-on output has been published in the British Journal of Pharmacology (doi/10.1111/bph.15304).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
