Automated Electrophysiological and Pharmacological Evaluation of Human Pluripotent Stem Cell-Derived Cardiomyocytes
- Submitting institution
-
University of Keele
- Unit of assessment
- 12 - Engineering
- Output identifier
- 382
- Type
- D - Journal article
- DOI
-
10.1089/scd.2015.0253
- Title of journal
- Stem Cells and Development
- Article number
- -
- First page
- 439
- Volume
- 25
- Issue
- 6
- ISSN
- 1547-3287
- Open access status
- Compliant
- Month of publication
- February
- Year of publication
- 2016
- URL
-
https://www.liebertpub.com/doi/full/10.1089/scd.2015.0253
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
7
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- A report detailing high-throughput automated evaluation of the electrophysiology and pharmacology of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Recognition of impact was secured via an invited cover art contribution for Stem Cells and Development Vol. 25, No. 6. Funding support was provided via British Heart Foundation (PG/09/027/27141), MRC (G113/30) and industrial collaboration with Nanion Technologies GmbH. Follow on studies included the NC3Rs’ Innovation Platform InPulse Challenge (sponsored by GSK) to develop a suite of assays to assess cardiac liabilities of drugs using hiPSC-CMs. A component of this work was included in D. Rajamohan’s successfully defended PhD thesis.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
