Immobilized WNT Proteins Act as a Stem Cell Niche for Tissue Engineering
- Submitting institution
-
University of Keele
- Unit of assessment
- 12 - Engineering
- Output identifier
- 409
- Type
- D - Journal article
- DOI
-
10.1016/j.stemcr.2016.06.004
- Title of journal
- Stem Cell Reports
- Article number
- -
- First page
- 126
- Volume
- 7
- Issue
- 1
- ISSN
- 2213-6711
- Open access status
- Compliant
- Month of publication
- July
- Year of publication
- 2016
- URL
-
https://www.sciencedirect.com/science/article/pii/S2213671116300960
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
4
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- Resulting from an MRC-UKRMP funded collaboration between Habib and El Haj, this work demonstrates for the first time that tethered Wnt proteins can be used to control asymmetric differentiation in a 3D niche model. This has significant impact for clinical applications in bone and cartilage repair. It formed a major platform for renewed MRC-UKRMP funding (2018-2022), enabled a collaboration with Orthopaedics, Cambridge (McCaskie) to develop novel solutions to treat Osteoarthritis, contributed to a Sir Henry Dale Fellowship (Habib), and resulted in invitations to speak at international meetings; e.g. ORS, San Diego (2017); ECM conference and AO Institute, Switzerland (2016).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
