Mesenchymal Stem Cell-Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis
                        
                        
                            - Submitting institution
 
                            - 
                                University of Keele
                                
 
                            
 
                            - Unit of assessment
 
                            - 12 - Engineering
 
                            - Output identifier
 
                            - 420
 
                            - Type
 
                            - D - Journal article
 
                                - DOI
 
                                - 
                                        10.1038/s41598-017-18144-w
                                
 
                                - Title of journal
 
                                - Scientific Reports
 
                                - Article number
 
                                - 18019
 
                                - First page
 
                                - -
 
                                - Volume
 
                                - 7
 
                                - Issue
 
                                - 1
 
                                - ISSN
 
                                - 2045-2322
 
                                - Open access status
 
                                - Compliant
 
                            - Month of publication
 
                            - December
 
                            - Year of publication
 
                            - 2017
 
                            - URL
 
                            - 
                                    
                                        https://www.nature.com/articles/s41598-017-18144-w
                                    
                            
 
                            - Supplementary information
 
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-                            
 
                            - Request cross-referral to
 
                            - -
 
                            - Output has been delayed by COVID-19
 
                            - No
 
                            - COVID-19 affected output statement
 
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                            - Forensic science
 
                            - No
 
                            - Criminology
 
                            - No
 
                            - Interdisciplinary
 
                            - No
 
                            - Number of additional authors
 
                            - 
                                7
                            
 
                            - Research group(s)
 
                            - 
-                            
 
                            - Proposed double-weighted
 
                            - No
 
                            - Reserve for an output with double weighting
 
                            - No
 
                            - Additional information
 
                            - This output demonstrated the therapeutic potential of mesenchymal stem cell-conditioned medium for the treatment of inflammatory arthritis.  Support was provided via the Dowager Countess Eleanor Peel Trust (AJT.1064.2.MJA (13/05)) and the Orthopaedic Institute Ltd (133). Follow-on funding was obtained from the Robert Jones and Agnes Hunt Orthopaedic Hospital Charity (G08028), a British Society for Immunology summer placement award, and a Keele University PhD studentship. This work led to subsequent publications (Hyland et al, 2020) and conference presentations (TERMIS World Congress, USA, 2015; 2nd Vinmec International Conference ‘Cell and Gene Therapy’, Vietnam, 2018). 
 
                            - Author contribution statement
 
                            - -
 
                            - Non-English
 
                            - No
 
                            - English abstract
 
                            - -