Non-invasive electrocardiogram detection of in vivo zebrafish embryos using electric potential sensors
- Submitting institution
-
University of Sussex
- Unit of assessment
- 12 - Engineering
- Output identifier
- 345380_57386
- Type
- D - Journal article
- DOI
-
10.1063/1.4935249
- Title of journal
- Applied Physics Letters
- Article number
- a193701
- First page
- -
- Volume
- 107
- Issue
- 19
- ISSN
- 0003-6951
- Open access status
- Out of scope for open access requirements
- Month of publication
- November
- Year of publication
- 2015
- URL
-
http://dx.doi.org/10.1063/1.4935249
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
3
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- We designed and built a non-invasive, cost-effective platform based on electric-field-sensing technology for the continuous detection of the cardiac-electrical activity in embryonic living zebrafish never carried out before. We present results showing ECG cardiac signals from 3 and 5 days-post-fertilization zebrafish embryos. The recorded waveforms show traces presenting similarities to those of the human heart. The strong evidence provided show that this technology will open future opportunities for drug-screening applications in the pharmaceutical industry. This paper has opened the collaboration with the drug screening company ZeClinics Spain (Dr. Sylvia Dyballa sylvia.dyballa@zeclinics.com).
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
