Part I: Minicircle vector technology limits DNA size restrictions on ex vivo gene delivery using nanoparticle vectors: Overcoming a translational barrier in neural stem cell therapy
- Submitting institution
-
University of Keele
- Unit of assessment
- 12 - Engineering
- Output identifier
- 427
- Type
- D - Journal article
- DOI
-
10.1016/j.jconrel.2016.06.024
- Title of journal
- Journal of Controlled Release
- Article number
- -
- First page
- 289
- Volume
- 238
- Issue
- -
- ISSN
- 0168-3659
- Open access status
- Compliant
- Month of publication
- June
- Year of publication
- 2016
- URL
-
https://www.sciencedirect.com/science/article/pii/S0168365916303923
- Supplementary information
-
-
- Request cross-referral to
- -
- Output has been delayed by COVID-19
- No
- COVID-19 affected output statement
- -
- Forensic science
- No
- Criminology
- No
- Interdisciplinary
- No
- Number of additional authors
-
1
- Research group(s)
-
-
- Proposed double-weighted
- No
- Reserve for an output with double weighting
- No
- Additional information
- The work provided the first demonstration that novel DNA vectors (‘minicircles’) and magnetofection achieve safe non-viral DNA transfection in primary NSCs. Through BBSRC (BB/F013884/1, BB/J017590/1) & EPSRC (EP/I017801/1) funded projects, Chari demonstrated the utility of ‘magnetofection’ technology in collaboration with Keele spin-off company nanoTherics Ltd. Seven postgraduate students subsequently utilised the methodology, including clinical transplant cell populations, to successfully gain PhDs/clinical MPhils.
- Author contribution statement
- -
- Non-English
- No
- English abstract
- -
